Abstract/Details

Synaptic change during C. elegans lethargus


2012 2012

Other formats: Order a copy

Abstract (summary)

Neurons change dramatically over the life-span, including developmentally and as a function of circadian and sleep::wake cycles. Understanding the molecular mechanisms of synaptic change under these conditions may provide insight into the fundamentals of nervous system function. The nematode Caenorhabditis elegans exhibits a developmental, circadian regulated sleep-like state—lethargus, ideal for this study. Plasticity at the neuromuscular junction during lethargus was examined pharmacologically, genetically, and optogenetically. Our findings suggested the following: (1) alterations in transmission at the neuromuscular junction depend on developmental timing and not behavioral state; (2) GABAergic synaptic transmission is reduced during lethargus; (3) a post-synaptic mechanism contributes to the reduced transmission during lethargus. Further, genetic studies aimed towards mechanism found that the alteration in transmission is genetically conferred. That is, both an EMS mutant and a naturally occurring strain without plasticity during lethargus were obtained.

Indexing (details)


Subject
Neurosciences;
Genetics;
Behavioral psychology;
Microbiology
Classification
0317: Neurosciences
0369: Genetics
0384: Behavioral psychology
0410: Microbiology
Identifier / keyword
Biological sciences, Psychology, C. elegans, Development, Gaba, Lethargus, Neuromuscular junction, Sleep, Synaptic plasticity
Title
Synaptic change during C. elegans lethargus
Author
Dabbish, Nooreen
Number of pages
87
Publication year
2012
Degree date
2012
School code
0175
Source
DAI-B 73/09(E), Dissertation Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
9781267351104
Advisor
Raizen, David M.
Committee member
Jongens, Tom; Kalb, Robert; Lamintina, Todd; Pack, Allan
University/institution
University of Pennsylvania
Department
Neuroscience
University location
United States -- Pennsylvania
Degree
Ph.D.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
3508989
ProQuest document ID
1019055669
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/1019055669
Access the complete full text

You can get the full text of this document if it is part of your institution's ProQuest subscription.

Try one of the following:

  • Connect to ProQuest through your library network and search for the document from there.
  • Request the document from your library.
  • Go to the ProQuest login page and enter a ProQuest or My Research username / password.