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Molecular Psychiatry (2016) 21, 15111516 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved 1359-4184/16
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ORIGINAL ARTICLE
Mast cells' involvement in inammation pathways linked to depression: evidence in mastocytosis
S Georgin-Lavialle1,2,3,20, DS Moura1,2,4,20, A Salvador5,6, J-C Chauvet-Gelinier7,8, J-M Launay9, G Damaj10, F Ct2, E Souci11, M-O Chandesris1, S Barte1,2, C Grandpeix-Guyodo1, C Bachmeyer3, M-A Alyanakian12, A Aouba13, O Lortholary1,14,P Dubreuil1,11, J-R Teyssier15, B Trojak6,7, E Haffen15,16,17, P Vandel17,18, B Bonin7,8, the French Mast Cell Study Group21,O Hermine1,2,13,22 and R Gaillard1,5,6,19,22
Converging sources of evidence point to a role for inammation in the development of depression, fatigue and cognitive dysfunction. More precisely, the tryptophan (TRP) catabolism is thought to play a major role in inammation-induced depression. Mastocytosis is a rare disease in which chronic symptoms, including depression, are related to mast cell accumulation and activation. Our objectives were to study the correlations between neuropsychiatric features and the TRP catabolism pathway in mastocytosis in order to demonstrate mast cells' potential involvement in inammation-induced depression. Fifty-four patients with mastocytosis and a mean age of 50.1 years were enrolled in the study and compared healthy age-matched controls. Depression and stress were evaluated with the Beck Depression Inventory revised and the Perceived Stress Scale. All patients had measurements of TRP, serotonin (5-HT), kynurenine (KYN), indoleamine 2,3-dioxygenase 1 (IDO1) activity (ratio KYN/TRP), kynurenic acid (KA) and quinolinic acid (QA). Patients displayed signicantly lower levels of TRP and 5-HT without hypoalbuminemia or malabsorption, higher IDO1 activity, and higher levels of KA and QA, with an imbalance towards the latter. High perceived stress and high depression scores were associated with low TRP and high IDO1 activity. In conclusion, TRP metabolism is altered in mastocytosis and correlates with perceived stress and
Molecular Psychiatry (2016) 21, 15111516; doi:http://dx.doi.org/10.1038/mp.2015.216
Web End =10.1038/mp.2015.216 ; published online 26 January 2016
INTRODUCTION
Converging sources of evidence point to a role for inammation in the development of depression, fatigue, and cognitive dysfunction.16 The major role of proinammatory cytokines has been well characterized, allowing to demonstrate that they interact with multiple pathways known to be involved in the development of depression, including monoamine metabolism, neuroendocrine function, synaptic plasticity and neurocircuits relevant to mood regulation. Studying patients treated with
interferon alpha has been very fruitful in...