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Abstract
Povzetek Izhodisca. Transferinski receptorji so transmembranski proteini, ki imajo kljucno vlogo v presnovi zeleza. Omogocajo transport na transferin vezanega zeleza v celice. Kadar je potreba po zelezu velika, celice pomnozijo transferinske receptorje. Koncentracija serumskih transferinskih receptorjev je sorazmerna koncentraciji membranskih receptorjev in odslikava celotno eritropoetsko dejavnost. Zakljucki. Topne receptorje lahko dolocamo v serumu z imunoloskimi preiskavami. Z merjenjem koncentracije transferinskih receptorjev v serumu lahko kolicinsko merimo stopnjo pomanjkanja zeleza in locimo med anemijo zaradi kronicnih bolezni in anemijo zaradi pomanjkanja zeleza. Pri stanjih s pospeseno eritropoezo lahko spremljamo aktivnost bolezni. Primerni so za spremljanje zdravljenja s humanim eritropoetinom. So zelo obcutljiv kazalec eritropoeze, pogosto lahko celo nadomestijo citoloski pregled kostnega mozga. Razlicna fizioloska stanja (nosecnost) in vnetja ne vplivajo na koncentracijo serumskih transferinskih receptorjev.
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