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Journal of Human Hypertension (2017) 31, 270277 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved 0950-9240/17
http://www.nature.com/jhh
Web End =www.nature.com/jhh
M Iida1, M Yamamoto1, Y Ishiguro1, M Yamazaki2, N Ueda2, H Honjo2 and K Kamiya2
Left atrial (LA) phasic volumes consist of reservoir, conduit and booster pump volumes. Arterial stiffness is linked to lower systemic arterial compliance (SAC) contributing to cardiac afterload. Arterial stiffness may be a modulator of LA phasic volumes. Echocardiography was performed in 161 hypertensive patients and in 50 normotensive subjects in order to assess biplane LA volumes (maximum, before atrial contraction, minimum), early and late diastolic mitral annular velocity (e and a), and LV stroke volume. LA emptying volumes (total, passive, active) were calculated from these LA volumes. Blood pressures were measured using an automated oscillometric device simultaneously at the four limbs for evaluating pulse pressure (PP) and anklebrachial index (ABI). SAC was estimated by the ratio of LV stroke volume indexed by body surface area (BSA) divided by PP. All three LA volumes, LA total volume and LA active emptying volume were greater in hypertensive patients than in normotensive subjects. A multiple linear regression analysis indicated that LA passive emptying volume (reservoir = early diastole)/BSA correlated positively with ABI after being adjusted for age, gender, BSA, LV mass, max LA volume, e and SAC in hypertensive patients. LA active emptying volume (booster = late diastole)/BSA correlated positively with SAC after being adjusted for age, gender, BSA, LV mass, LA volume before atrial contraction, a and ABI. LA reservoir volume was associated with ABI, and LA booster volume was related to systemic arterial
Journal of Human Hypertension (2017) 31, 270277; doi:http://dx.doi.org/10.1038/jhh.2016.74
Web End =10.1038/jhh.2016.74 ; published online 13 October 2016
INTRODUCTION
Atrial function contributes considerably to the modulation of cardiac output. Left atrial (LA) volume consists of three phases: reservoir, conduit and booster pump volumes.1 The reservoir volume is governed by pulmonary vein inow during early ventricular systole, the conduit volume is determined by pulmonary vein inow during early ventricular diastole and the booster function reects atrial contractility during late ventricular diastole to augment ventricular lling.2
Enlargement of LA volume could be attributable to the severity of diastolic dysfunction in patients without a history of atrial arrhythmias or...