Full Text

Turn on search term navigation

© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Surfactants are essential in the manufacture of polymeric nanoparticles by emulsion formation methods and to preserve the stability of carriers in liquid media. The deposition of non-ionic surfactants at the interface allows a considerable reduction of the globule of the emulsion with high biocompatibility and the possibility of oscillating the final sizes in a wide nanometric range. Therefore, this review presents an analysis of the three principal non-ionic surfactants utilized in the manufacture of polymeric nanoparticles; polysorbates, poly(vinyl alcohol), and poloxamers. We included a section on general properties and uses and a comprehensive compilation of formulations with each principal non-ionic surfactant. Then, we highlight a section on the interaction of non-ionic surfactants with biological barriers to emphasize that the function of surfactants is not limited to stabilizing the dispersion of nanoparticles and has a broad impact on pharmacokinetics. Finally, the last section corresponds to a recommendation in the experimental approach for choosing a surfactant applying the systematic methodology of Quality by Design.

Details

Title
Non-Ionic Surfactants for Stabilization of Polymeric Nanoparticles for Biomedical Uses
Author
Cortés, Hernán 1   VIAFID ORCID Logo  ; Hernández-Parra, Héctor 2 ; Bernal-Chávez, Sergio A 3 ; Del Prado-Audelo, María L 4   VIAFID ORCID Logo  ; Caballero-Florán, Isaac H 5 ; Borbolla-Jiménez, Fabiola V 1 ; González-Torres, Maykel 6   VIAFID ORCID Logo  ; Magaña, Jonathan J 7   VIAFID ORCID Logo  ; Leyva-Gómez, Gerardo 3   VIAFID ORCID Logo 

 Laboratorio de Medicina Genómica, Departamento de Genómica, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de México 14389, Mexico; hcortes@inr.gob.mx (H.C.); fvbj@hotmail.com (F.V.B.-J.) 
 Departamento de Farmacología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México 07360, Mexico; hector.hernandez@cinvestav.mx (H.H.-P.); hiram.qfohead@gmail.com (I.H.C.-F.) 
 Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico; q901108@hotmail.com 
 Escuela de Ingeniería y Ciencias, Departamento de Bioingeniería, Tecnológico de Monterrey Campus Ciudad de México, CDMX, Ciudad de México 14380, Mexico; luisa.delpradoa@gmail.com 
 Departamento de Farmacología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México 07360, Mexico; hector.hernandez@cinvestav.mx (H.H.-P.); hiram.qfohead@gmail.com (I.H.C.-F.); Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico; q901108@hotmail.com 
 CONACyT-Laboratorio de Biotecnología, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de México 14389, Mexico; mikegcu@gmail.com 
 Laboratorio de Medicina Genómica, Departamento de Genómica, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de México 14389, Mexico; hcortes@inr.gob.mx (H.C.); fvbj@hotmail.com (F.V.B.-J.); Escuela de Ingeniería y Ciencias, Departamento de Bioingeniería, Tecnológico de Monterrey Campus Ciudad de México, CDMX, Ciudad de México 14380, Mexico; luisa.delpradoa@gmail.com 
First page
3197
Publication year
2021
Publication date
2021
Publisher
MDPI AG
e-ISSN
19961944
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2545008933
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.