Abstract/Details

Characterizations of B lymphocyte responses during infection with African trypanosomes


2008 2008

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Abstract (summary)

Host control of Trypanosoma brucei infections relies on adequate B cell mediated responses including anti-VSG antibody responses. Trypanotolerant animals, namely; Cape buffalo maintain anti-trypanosome specific antibody responses throughout infection. Studies in mice, however; show a failure to maintain adequate antibody responses to trypanosomes as well as a failure to generate subsequent specific responses to antigens. T. brucei infections in mice result in the loss of mature conventional B cell subsets presumed to be important in host control of the parasites including marginal zone B cells and follicular B cells. Mature cell subset losses are coupled with plasma cell expansion early during infection. Mature B cell pools are not replenished as there is a loss of transitional cells due in part to higher levels of apoptosis and a failure to replenish these cells from bone marrow. B1 B cells appear to constitute the majority of plasma cells and resist infection induced losses to a greater extant than B2 B cells.

Indexing (details)


Subject
Veterinary services;
Immunology
Classification
0778: Veterinary services
0982: Immunology
Identifier / keyword
Health and environmental sciences, Biological sciences, B lymphocytes, Hematopoiesis, Immune responses, Trypanosoma brucei, Trypanosomes
Title
Characterizations of B lymphocyte responses during infection with African trypanosomes
Author
Guirnalda, Patrick David
Number of pages
162
Publication year
2008
Degree date
2008
School code
0118
Source
DAI-B 69/08, Dissertation Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
9780549663652
Advisor
Black, Samuel J.
Committee member
Alfandari, Dominique; Klingbeil, Michele; Telfer, Janice
University/institution
University of Massachusetts Amherst
Department
Animal Science
University location
United States -- Massachusetts
Degree
Ph.D.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
3315487
ProQuest document ID
230672627
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/230672627
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