Abstract/Details

Control and modification of the structure and properties of associative network polymer hydrogels


2007 2008

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Abstract (summary)

Polymeric systems that have a 'sticky' functional group along their backbone tend to physically associate in solution leading to formation of interesting self-assembled structures. Continued association between these self assembled domains eventually leads to formation of a three-dimensional network structure. This dissertation describes our study of the structure-property-activity relationship of such an associative network structure formed by triblock copolymers of poly (lactide)-poly(ethylene oxide)-poly(lactide) (PLA-PEO-PLA). The relationship between the chemistry of the starting polymer, the nano- and micro-scale structure of the polymer in solution and gel state and the macroscopic properties of the associative network solutions and hydrogels formed by the polymer was obtained by using a combination of various characterization techniques such as light scattering, small angle neutron/X-ray scattering, ultra small angle neutron/X-ray scattering and dynamic mechanical rheology. The rheological properties and drug release characteristics of these polymers were seen to be very closely dependent upon the nanoscale structure of the materials which in turn can be directly controlled by modifying the chemistry of the starting polymer. Based upon our understanding of the relationship as described above, we further modified the nanoscale structure and thereby the properties of the polymer gels by addition of small amounts of specific inorganic nanoparticles that act as new 'sticky' domains in the polymer network. In particular, the mechanical properties of the hydrogels were seen to be significantly enhanced by addition of nanoparticles.

Indexing (details)


Subject
Chemical engineering
Classification
0542: Chemical engineering
Identifier / keyword
Applied sciences; Associative network polymers; Bionanotechnology; Crosslink network; Drug delivery; Polymer gels; Polymer hydrogels; Rheology; Small angle scattering
Title
Control and modification of the structure and properties of associative network polymer hydrogels
Author
Agrawal, Sarvesh Kumar
Number of pages
193
Publication year
2007
Degree date
2008
School code
0118
Source
DAI-B 69/08, Dissertation Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
9780549663713
Advisor
Bhatia, Surita R.
Committee member
Forbes, Neil S.; Tew, Gregory N.
University/institution
University of Massachusetts Amherst
Department
Chemical Engineering
University location
United States -- Massachusetts
Degree
Ph.D.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
3315493
ProQuest document ID
230679049
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/230679049
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