Abstract/Details

THE PHARMACOGNOSY OF SALVIA DIVINORUM (EPLING AND JATIVA-M): AN INVESTIGATION OF SKA MARIA PASTORA (MEXICO)


1983 1983

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Abstract (summary)

Salvia divinorum (Epling and Jativa-M.) is a perennial labiate used for curing and divination by the Mazatec Indians of Oaxaca, Mexico. The psychotropic effects the plant produces are compared to those of the other hallucinogens employed by the Mazatecs; the morning glory, Rivea corymbosa, L., Hallier, F., and psilocybin containing mushrooms. A discussion of the role of ska Mar(')ia Pastora in the native "pharmacopeia" is based on previous reports and fieldwork by the investigator with a Mazatec shaman.

Two new neoclerodane diterpenes, divinorins A and B were isolated from S. divinorum. Divinorin A exerts a sedative effect on mice when tested in a bioassay using a modification of Hall's open field test. The structures of divinorins A and B were elucidated based on extensive proton and carbon-13 nmr experiments using the divinorins and their reduction products. The structure of divinorin A was confirmed by a single-crystal x-ray diffraction experiment employing standard refinement techniques. The absolute configurations of the divinorins have been proposed on the basis of their negative Cotton effects near 290 nm.

Indexing (details)


Subject
Pharmacology
Classification
0491: Pharmacology
Identifier / keyword
Pure sciences
Title
THE PHARMACOGNOSY OF SALVIA DIVINORUM (EPLING AND JATIVA-M): AN INVESTIGATION OF SKA MARIA PASTORA (MEXICO)
Author
VALDES, LEANDER JEROME JULIAN, III
Number of pages
253
Publication year
1983
Degree date
1983
School code
0127
Source
DAI-B 44/10, Dissertation Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
University/institution
University of Michigan
University location
United States -- Michigan
Degree
Ph.D.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
8402393
ProQuest document ID
303280881
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/303280881
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