The spatial vision of monkeys with experimentally induced strabismus

1991 1991

Other formats: Order a copy

Abstract (summary)

In the human population, amblyopia is very often associated with strabismus. To investigate the neural basis of strabismic amblyopia, we developed an animal model by producing esotropic strabismus in young infant macaque monkeys (Macaca nemestrina). The aim of this thesis was to characterize the spatial vision of monkeys raised with experimental strabismus. Specifically, we first established the validity of this animal model by comparing the monkeys' deficits in several spatial vision tasks to those of humans with strabismic amblyopia. Second, we tested the specific hypothesis that all the spatial vision deficits of strabismic amblyopes could be explained by a global impairment in their ability to process contrast signals. Finally, we provided a set of quantitative measures of visual performance that will serve as a basis for subsequent physiological investigations.

Using standard operant methods, we measured contrast sensitivity, spatial resolution, Vernier acuity, spatial phase discrimination and suprathreshold contrast discrimination in five strabismic and one normal monkeys. In addition, we used a masking paradigm to obtain information about the characteristics of the visual mechanisms underlying the monkeys' performance in these tasks.

We found that monkeys with experimental strabismus could exhibit deficits in each of the visual functions tested. The deviated eye's performance was impaired compared to the fellow and normal eyes, especially for stimuli with medium to high spatial frequencies. The fellow eyes' performance did not significantly differ from that of the normal eyes. The strabismic monkeys' deficits resembled those of humans with strabismic amblyopia. This similarity in the pattern of deficits validates the use of this animal model for the study of the neural basis of strabismic amblyopia. Finally, for monkeys with severe amblyopia, we found that the deficits in contrast processing could not completely explain their deficits in the other spatial vision tasks. This suggests that in addition to a deficit in contrast processing, one or more additional factors contribute to the poor spatial vision of strabismic amblyopes.

Indexing (details)

0623: Psychology
0623: Experiments
Identifier / keyword
The spatial vision of monkeys with experimentally induced strabismus
Kiper, Daniel Charles
Number of pages
Publication year
Degree date
School code
DAI-B 52/12, Dissertation Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
Movshon, J. Anthony
New York University
University location
United States -- New York
Source type
Dissertations & Theses
Document type
Dissertation/thesis number
ProQuest document ID
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
Access the complete full text

You can get the full text of this document if it is part of your institution's ProQuest subscription.

Try one of the following:

  • Connect to ProQuest through your library network and search for the document from there.
  • Request the document from your library.
  • Go to the ProQuest login page and enter a ProQuest or My Research username / password.