Abstract/Details

Modeling single probe cryosurgery


1998 1998

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Abstract (summary)

A time dependent three dimensional model of iceball formation about a single cryoprobe is described and extensively compared to experimental data. A realistic three dimensional probe geometry is specified and cryoprobe temperature may be arbitrarily set as a function of time in the model. Thermal histories for several points around a CRYOprobe$\sp{\rm TM}$ have been predicted to high accuracy. Temperature distributions with time within iceballs are presented and compared to the results of the infinite cylinder equilibrium solution of the Fourier heat equation. Infinite cylinder approximations are shown to be grossly inaccurate. A novel concept, termed the ablative ratio, is introduced as the ratio of the volume of ablated tissue divided by the total volume of the iceball. This concept assumes necrosis occurs when cells have been dropped below some critical temperature. For the purposes of illustration, we will assume a $-20\sp\circ$C isotherm completely kills target tissue. The simulated results indicate that the killing efficiency of an iceball, as measured by the ablative ratio, decreases with time as the iceball increases with size. Calculations of isotherm locations with the infinite cylinder solution are shown to yield overestimates of the ablative ratio.

Indexing (details)


Subject
Surgery
Classification
0564: Surgery
Identifier / keyword
Health and environmental sciences
Title
Modeling single probe cryosurgery
Author
Rewcastle, John Cameron
Number of pages
65
Publication year
1998
Degree date
1998
School code
0026
Source
MAI 37/02M, Masters Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
9780612313712, 0612313719
Advisor
Sandison, George A.
University/institution
University of Calgary (Canada)
University location
Canada
Degree
M.Sc.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
MQ31371
ProQuest document ID
304431774
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/304431774/abstract
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