Abstract/Details

Effect of oxidative stress on histidine containing dipeptides, conjugated linoleic acid and alpha-tocopherol in animal and human muscle


1999 1999

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Abstract (summary)

Skeletal muscle contains a number of endogenous antioxidants that aid in protecting the muscle from oxidative damage. Antioxidant systems are comprised of water and lipid soluble compounds. The histidine containing dipeptides, anserine and carnosine, and α-tocopherol represent water and lipid soluble antioxidants which protect the muscle from oxidative damage. Raw and cooked turkey thigh and breast muscle were oxidatively challenged in order to understand the role of water and lipid soluble antioxidants in protecting the muscle from oxidative damage. The data suggest both water soluble and lipid soluble antioxidants affect the oxidative stability of turkey muscle.

Conjugated linoleic acid (CLA) was supplemented in the diets of rats in order to ascertain the antioxidant capacity of rat liver microsomes and muscle homogenates after up to 48 hr oxidation. CLA was shown to alter the fatty acid profile but was not shown to be as effective as α-tocopherol.

Trained and untrained muscle biopsies were oxidatively stressed for 3 hrs. Trained muscle homogenates exhibited lower hexanal formation and reduced α-tocopherol loss. Supplementation of untrained subjects failed to improve the oxidative stability of the muscle.

Indexing (details)


Subject
Food science;
Molecular biology;
Biochemistry
Classification
0359: Food science
0307: Molecular biology
0487: Biochemistry
Identifier / keyword
Pure sciences, Biological sciences, Conjugated linoleic acid, Dipeptides, Histidine-containing, Muscle, Oxidative stress, Tocopherol
Title
Effect of oxidative stress on histidine containing dipeptides, conjugated linoleic acid and alpha-tocopherol in animal and human muscle
Author
Livisay, Stacy Ann
Number of pages
99
Publication year
1999
Degree date
1999
School code
0118
Source
DAI-B 60/11, Dissertation Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
0599530383, 9780599530386
Advisor
Decker, Eric
University/institution
University of Massachusetts Amherst
University location
United States -- Massachusetts
Degree
Ph.D.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
9950183
ProQuest document ID
304535320
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/304535320
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