Abstract/Details

PLA-PEO-PLA triblock copolymer hydrogels for soft tissue engineering: Properties, assembly, and structure


2008 2008

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Abstract (summary)

Biodegradable hydrogels show great promise in the area of biomaterials and specifically for tissue engineering applications. While much work in the past has studied the various biochemical signals associated with cell growth, more recent work has highlighted the importance of the mechanical environment as a stimulus for growth. This dissertation focuses on associative network hydrogels formed for poly(lactide)-b-poly(ethylene oxide)-b-poly(lactide) [PLA-PEO-PLA] triblock copolymers and the factors that influence their mechanical properties, assembly, and structure. By controlling the stereospecificity of the PLA endblocks hydrogels with either amorphous or crystalline hydrophobic domains were formed as characterized using both X-ray and neutron scattering techniques. This change in structure directly impacted the mechanical properties of the hydrogels. Furthermore, complications in synthetic techniques introduced contaminants (asymmetric triblock copolymers or "effective" diblock copolymers) that impacted the assembly of the network to again impact the mechanical properties. Ultimately, the PLA-PEO-PLA triblock copolymer was chemically modified so that the self-assembled physical network served as a template for the covalently crosslinked network formed by photocrosslinking. The photocrosslinked hydrogels maintained their mechanical integrity in an aqueous environment; however, the measured mechanical properties were dependent on the assumed constitutive relationship.

Indexing (details)


Subject
Polymer chemistry;
Biomedical engineering
Classification
0495: Polymer chemistry
0541: Biomedical engineering
Identifier / keyword
Applied sciences; Pure sciences; Hydrogels; Hydrophobic domains; Tissue engineering; Triblock copolymers
Title
PLA-PEO-PLA triblock copolymer hydrogels for soft tissue engineering: Properties, assembly, and structure
Author
DeLong, Naomi Sanabria
Number of pages
155
Publication year
2008
Degree date
2008
School code
0118
Source
DAI-B 69/12, Dissertation Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
9780549915201
Advisor
Tew, Gregory N.
Committee member
Bhatia, Surita R.; Crosby, Alfred J.
University/institution
University of Massachusetts Amherst
Department
Polymer Science & Engineering
University location
United States -- Massachusetts
Degree
Ph.D.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
3336934
ProQuest document ID
304565753
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/304565753
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