Abstract/Details

A transannular Cope approach toward the core structure of isocyclocitrinol


2008 2008

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Abstract (summary)

This thesis describes the efforts of Professor James Leighton and myself toward the construction of the core structure of isocyclocitrinol. Our first two approaches toward the 10-membered ring system using ring closing metathesis are discussed. The next chapter discusses the new approaches toward the synthesis of the cyclopentane piece cumulating in the successful epoxy-silane approach. The next three chapters discuss the macrocyclic Suzuki, ketene-aldeyde [2+2], and Ramberg-Bäcklund strategy. Finally, our efforts in performing a ring-contracting Ireland-Claisen reaction for the construction of the 10-membered ring are discussed.

Indexing (details)


Subject
Organic chemistry
Classification
0490: Organic chemistry
Identifier / keyword
Pure sciences; Ireland-Claisen reaction; Isocyclocitrinol; Macrolactones; Ring-closing metathesis; Transannular Cope
Title
A transannular Cope approach toward the core structure of isocyclocitrinol
Author
Soheili, Arash
Number of pages
168
Publication year
2008
Degree date
2008
School code
0054
Source
DAI-B 69/10, Dissertation Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
9780549856009
Advisor
Leighton, James L.
University/institution
Columbia University
University location
United States -- New York
Degree
Ph.D.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
3333478
ProQuest document ID
304622424
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/304622424/abstract
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