Abstract/Details

Acute regulation of IGF -1 by differential binding protein expression, inhibition, and proteolysis


2008 2008

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Abstract (summary)

The purposes of this investigation were to examine the acute regulation of IGF-1 via insulin-like growth factor binding-protein (IGFBP) expression, inhibition, and proteolysis. Eight recreationally-active college-aged males completed three identical high-intensity interval training protocols followed by each of three randomly ordered post-exercise nutritional protocols: (1) non-caloric placebo; (2) carbohydrate-only (0.85 g/kg lbw); and (3) essential amino acid/carbohydrate (0.35 g/kg and 0.5 g/kg lbw, respectively). Blood samples were obtained pre-exercise, immediately post-exercise, at ten minute intervals for 80 minutes post-exercise, and at 20 minute intervals until 160 minutes post-exercise. Blood samples were analyzed for GH, free IGF-1, insulin, hematocrit, hemoglobin, plasma amino acid concentrations, and matrix metalloproteinase (MMP) activity. Analytes were compared relative to baseline and across conditions using ANOVAs with repeated measures. Additionally, total area under the curve scores were calculated for insulin and analyzed using one-way ANOVAs with repeated measures on condition. The a priori significance level for all analyses was p < 0.05. Significant post-exercise increases in free IGF-1 concentrations were observed in the essential amino acid/carbohydrate group only. Additionally, significant increases in post-exercise MMP activity were observed in all groups. These results indicate that post-exercise macronutrient ratio is a determinant of free concentrations of IGF-1 and that high-intensity exercise results in increased MMP activity.

Indexing (details)


Subject
Nutrition;
Kinesiology;
Physiology
Classification
0570: Nutrition
0575: Kinesiology
0719: Physiology
Identifier / keyword
Health and environmental sciences; Biological sciences; Differential binding protein; IGF-1; IGF-1 regulation; IGFBP; Proteolysis
Title
Acute regulation of IGF -1 by differential binding protein expression, inhibition, and proteolysis
Author
Foster, Ernest Byron, II
Number of pages
96
Publication year
2008
Degree date
2008
School code
0012
Source
DAI-B 69/10, Dissertation Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
9780549853862
Advisor
Pascoe, David D.
University/institution
Auburn University
University location
United States -- Alabama
Degree
Ph.D.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
3333125
ProQuest document ID
304689468
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/304689468
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