Abstract/Details

Biomedical applications of carbon nanotubes


2009 2009

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Abstract (summary)

Nano-biotechnology is a multidisciplinary field that bridges physical sciences with biological sciences via chemical tools. Carbon nanotubes with small sizes, unique one dimensional aromatic structure, and interesting inherent physical, especially optical, properties, have shown promise in biology and medicine. This thesis is a comprehensive study of using single walled carbon nanotubes (SWNT) for in vitro and in vivo biomedical applications. In vitro siRNA delivery by SWNTs into 'hard-to-transfect' cells is reported. Drug loading on functionalized SWNTs by supramolecular chemistry is developed for targeted delivery of aromatic cancer drugs to specific types of cancer cells. Next, in vivo biodistribution of SWNTs is monitored by a radiolabeling methodology, as well as ex-vivo Raman spectroscopy. The latter provides long-term fate and excretion information of SWNTs in mice. It is found that the surface chemistry of SWNTs largely governs their in vivo behaviors. Prolonged blood circulation, reduced uptake in reticuloendothelial systems (RES) and accelerated excretion are all achieved for SWNTs with superior biocompatible surface coating. Efficient in vivo tumor targeting is also realized by conjugating a targeting peptide to biocompatible SWNTs. After those fundamental explorations, in vivo cancer treatment by SWNT delivery is validated in xenograft mouse models with two chemotherapy drugs, paclitaxel and doxorubicin, loaded on nanotubes in two separate studies. Furthermore, isotope composition-dependent Raman spectroscopy signatures of SWNTs are used for multiple color Raman imaging. In addition to SWNTs, a novel carbon based nanomaterial, nano-graphene oxide, is synthesized and used for drug loading and delivery. Taken together, carbon nanotubes and related nano-biotechnologies are likely to provide new opportunities for challenging problems in biomedicine such as cancer treatment and imaging.

Indexing (details)


Subject
Physical chemistry;
Biophysics
Classification
0494: Physical chemistry
0760: Biophysics
Identifier / keyword
Pure sciences; Biological sciences; Biological imaging; Carbon nanotubes; Drug delivery; Single-walled carbon nanotubes
Title
Biomedical applications of carbon nanotubes
Author
Liu, Zhuang
Number of pages
215
Publication year
2009
Degree date
2009
School code
0212
Source
DAI-B 70/01, Dissertation Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
9780549989806
Advisor
Dai, Hongjie
University/institution
Stanford University
University location
United States -- California
Degree
Ph.D.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
3343857
ProQuest document ID
304999786
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/304999786
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