Abstract/Details

Chemical approaches to study protein and lipid phosphorylation


2005 2005

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Abstract (summary)

Protein and lipid kinases direct signal transduction by the phosphorylation of their substrates. Elucidating kinase-mediated signaling pathways and validating specific kinases as targets for drug development are central goals of biomedical research. Chapter 1 describes the biochemical criteria that define the potency and selectivity of kinase inhibitors in cells. Chapter 2 describes a chemical strategy for targeting proteolysis to sites of protein phosphorylation. Chapter 3 describes isoform-specific inhibitors of PI3-kinase based on an arylmorpholine scaffold. Chapter 4 describes the role of the gatekeeper residue in PI3-kinases in controlling inhibitor sensitivity. Chapter 5 describes a pharmacological map of the PI3-K family and the role of PI3-K isoforms in insulin signaling.

Indexing (details)


Subject
Biochemistry
Classification
0487: Biochemistry
Identifier / keyword
Pure sciences; PI-3 kinase; Phosphorylation
Title
Chemical approaches to study protein and lipid phosphorylation
Author
Knight, Zachary A.
Number of pages
257
Publication year
2005
Degree date
2005
School code
0034
Source
DAI-B 66/12, Dissertation Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
9780542460517, 0542460513
Advisor
Shokat, Kevan M.
University/institution
University of California, San Francisco
University location
United States -- California
Degree
Ph.D.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
3199361
ProQuest document ID
305003564
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/305003564
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