Synthesis and characterization of novel carbosilane dendrimers as supports
Cyclic siloxane and polyhedral oligomeric silsesquioxane cages were used as core elements in the synthesis of vicinal amino alcohol capped dendrimers. Through divergent, repetitive hydrosilation/vinylation, dendrimers with varying degrees of branching were produced. Vinyl termini were subjected to hydrosilation, and subsequent hydrogenation to yield silyl hydride termini, which were then reacted with vinylbenzylchloride via hydrosilation to give dendrimers with benzyl chloride linkers. In separate studies, R-4-hydroxyphenylglycine was reduced to its corresponding amino alcohol, and methods for side chain attachment were considered.