Abstract/Details

Self -organization of biological systems: Protein folding and supramolecular assembly


2004 2004

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Abstract (summary)

Living systems exhibit collective behaviors characterized by hierarchical modules organized on multiple spatiotemporal scales. At its most basic level, this organization is reflected in spontaneous folding of biological macromolecules, and robust coherence of cellular metabolism. This dissertation offers a systematic quantification of thermodynamic and kinetic modes of emergence of order in a simple model of protein folding, and a general formalization of the physical mechanisms and functional significance of supramolecular protein self-assembly. These findings should prove useful in understanding the general principles of biological self-organization and its therapeutic application towards treatment of disease.

Indexing (details)


Subject
Biophysics;
Molecular biology;
Molecules
Classification
0786: Biophysics
0307: Molecular biology
0609: Molecules
Identifier / keyword
Pure sciences, Biological sciences, Protein folding, Self-organization, Supramolecular assembly
Title
Self -organization of biological systems: Protein folding and supramolecular assembly
Author
Kentsis, Alex
Number of pages
381
Publication year
2004
Degree date
2004
School code
1353
Source
DAI-B 65/02, Dissertation Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
Advisor
Borden, Katherine; Osman, Roman
University/institution
Mount Sinai School of Medicine of New York University
University location
United States -- New York
Degree
Ph.D.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
3120743
ProQuest document ID
305044026
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/305044026
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