Abstract/Details

Stability of hippocampal place cell activity across the rat estrous cycle


2004 2004

Other formats: Order a copy

Abstract (summary)

A large amount of research has focused on how the hippocampus encodes spatial information in an environment. Both in vitro and in vivo studies have demonstrated that estrogen exerts pronounced effects on hippocampal morphology and physiology. Examining the degree to which these molecular changes influence hippocampal processing in freely behaving animals was the goal of this research.

The estrogen effects on hippocampal morphology and plasticity are reviewed. This is followed by an examination of the impact of the estrous cycle on hippocampus related behaviors. A study is presented demonstrating sex and estrous cycle differences in activity and exploration of a novel environment.

The hippocampus (via the entorhinal cortex) integrates information from a wide range of brain regions. The pyramidal neurons in the CA1 region of the hippocampus transmit the outcome of the hippocampal processing back to the neocortex (via the subiculum and entorhinal cortex). The effect of the estrous cycle on these pyramidal neurons was examined in naturally cycling rats. Single unit recordings were conducted in rats both at rest on a holder and while running on the maze. A decrease in mean firing rate on the maze was found during proestrus. However, other basic measures of spatial tuning and burst properties remained stable across the cycle. The results suggest that molecular changes occurring over the estrous cycle are not directly reflected at the single unit level and may be dependent upon task demands or novelty of the environment.

Indexing (details)


Subject
Physiological psychology;
Neurology
Classification
0989: Physiological psychology
0317: Neurology
Identifier / keyword
Psychology, Biological sciences, Estrous cycle, Hippocampal, Place cell
Title
Stability of hippocampal place cell activity across the rat estrous cycle
Author
Tropp, Jennifer
Number of pages
76
Publication year
2004
Degree date
2004
School code
0056
Source
DAI-B 65/03, Dissertation Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
Advisor
Markus, Etan
University/institution
University of Connecticut
University location
United States -- Connecticut
Degree
Ph.D.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
3127599
ProQuest document ID
305211322
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/305211322
Access the complete full text

You can get the full text of this document if it is part of your institution's ProQuest subscription.

Try one of the following:

  • Connect to ProQuest through your library network and search for the document from there.
  • Request the document from your library.
  • Go to the ProQuest login page and enter a ProQuest or My Research username / password.