Abstract/Details

Altered mechanisms of fever in aged rats: From periphery to brain


2004 2004

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Abstract (summary)

Fever can be induced with lipopolysaccharides (LPS), endotoxins released from Gram-negative bacteria. LPS stimulates the immune system to produce cytokines, some of which (e.g. interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-alpha (TNFα)) are proinflammatory and elicit fever responses. Peripherally induced proinflammatory cytokines ultimately reach the brain and cause the synthesis and release of prostaglandin E2, which initiates behavioral, autonomic and endocrine responses necessary to raise body temperature (Tb). Previously we reported that old rats show blunted fevers compared to young rats when they are maintained at standard room temperatures (21–24°C), but will generate fevers similar to those of young rats when they are either allowed to choose a warmer ambient temperature (Ta) or are housed at a warmer Ta. This dissertation examined age-related differences in two parts of the fever pathway at a standard Ta (21°C) and a warmer Ta (31°C): (1) heat production and heat loss during fever in young and old rats at 21 and 31°C and (2) the passage of the proinflammatory cytokine IL-1β from blood to brain at the two Tas. In brief, we found that in contrast to the other three groups, which all showed good fever responses to LPS, old rats at 21°C showed a decline in metabolic rate and a concomitant lower passage of IL-1β into the brain.

Indexing (details)


Subject
Psychobiology
Classification
0349: Psychobiology
Identifier / keyword
Psychology; Aging; Brain; Fever; Lipopolysaccharides
Title
Altered mechanisms of fever in aged rats: From periphery to brain
Author
Buchanan, Jessica B.
Number of pages
76
Publication year
2004
Degree date
2004
School code
0060
Source
DAI-B 65/08, Dissertation Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
0496030221, 9780496030224
Advisor
Satinoff, Evelyn
University/institution
University of Delaware
University location
United States -- Delaware
Degree
Ph.D.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
3144783
ProQuest document ID
305217082
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/305217082
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