Abstract/Details

Nanoparticle-directed biomolecular recognition


2006 2006

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Abstract (summary)

Biomolecular recognition mediated by non-covalent complementary interactions is a powerful tool for regulation of numerous biological processes and the natural self-assembly of biomolecules into hierarchical structures. We have demonstrated that organically tailored nanoparticles provide versatile scaffolds for surface recognition of biomolecules, such as peptides and proteins, mediated by complementary surface interactions for applications in biology and materials science. Through the use of these supramolecular receptors, we have displayed efficient recognition and targeting of complementary peptide helices, control over protein structure and function and the use of an intracellular component for reversal of nanoparticle-directed protein inhibition. Additionally, we have also demonstrated the use of proteins for self-assembly of gold nanoparticles into controlled composites featuring tunable physical characteristics and collective optical response.

Indexing (details)


Subject
Chemistry
Classification
0485: Chemistry
Identifier / keyword
Pure sciences, Biomolecular recognition, Nanoparticle-directed, Proteins, Supramolecular
Title
Nanoparticle-directed biomolecular recognition
Author
Verma, Ayush
Number of pages
175
Publication year
2006
Degree date
2006
School code
0118
Source
DAI-B 67/11, Dissertation Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
9780542977053
Advisor
Rotello, Vincent M.
University/institution
University of Massachusetts Amherst
University location
United States -- Massachusetts
Degree
Ph.D.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
3242301
ProQuest document ID
305305864
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/305305864
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