Abstract/Details

Maintaining respect at the margins of agency: Respect for persons and research in emergency settings


2006 2006

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Abstract (summary)

Background. The principle of respect for persons is widely considered one of the three central principles of research ethics. However, it remains unclear what respect demands when conducting research, particularly with non-autonomous persons. This problem is particularly acute in research in emergency settings, where any form of consent is often impossible.

Objective. This project's objectives were: (1) to explore the meaning of respect for persons, particularly in research with non-autonomous persons; (2) to understand the range and nature of patients' views of emergency research; and (3) to articulate practical and policy recommendations for respectful conduct of emergency research.

Methods. This project involved two principal components that were mutually informative. The first was a conceptual analysis of respect for persons and involved reviewing existing literature and developing an account of the central elements of respect. The second component was an exploratory qualitative interview study. 19 survivors of sudden cardiac death were interviewed using an interview guide including questions about the meaning of respect and seven scenarios describing different types of research conducted in emergency settings without consent.

Results. An account of the major elements of respect was developed that is based on understanding what is important and valuable about persons. Consistent with views expressed by participants, respect includes elements of care, empathy, attention, comportment, and dignity, as well as recognition of autonomy. In research with nonautonomous subjects, respect demands protections in ways that it does not with persons who are autonomous. Patients interviewed were generally accepting of research in emergency settings, including the impracticability of consent, the need for randomization, and some potential for harm. The primary criterion by which patients evaluated studies was the level of risk and benefit involved.

Conclusion. Respect for persons entails a broader range of requirements than has traditionally been acknowledged. When conducting research in emergency settings, respect requires that subjects not be exposed to unreasonable risks, that potential participants be involved in determining the acceptability of studies, and that enrolled patients are treated with concern and attention. In order to facilitate respectful research, some current regulatory requirements may need to be removed and others clarified.

Indexing (details)


Subject
Public health;
Surgery;
Emergency services;
Research;
Ethics
Classification
0573: Public health
0564: Surgery
Identifier / keyword
Health and environmental sciences; Bioethics; Emergency; Ethics; Respect
Title
Maintaining respect at the margins of agency: Respect for persons and research in emergency settings
Author
Dickert, Neal Workman, Jr.
Number of pages
186
Publication year
2006
Degree date
2006
School code
0098
Source
DAI-B 67/04, Dissertation Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
9780542643224
Advisor
Kass, Nancy
University/institution
The Johns Hopkins University
University location
United States -- Maryland
Degree
Ph.D.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
3213690
ProQuest document ID
305318543
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/305318543
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