Abstract/Details

Syntheses and biological evaluation of potentially active sydnone analogues


2005 2005

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Abstract (summary)

A series of mesoionic compounds (sydnones) were synthesized and evaluated for anticancer and anti-inflammatory activities. The first series of sydnones was designed as potential anti-cancer drugs based on two lead compounds developed by Grynberg et al. Another series of sydnones was designed as potential anti-inflammatory agents based on structural similarities between sydnones and rofecoxib and celecoxib. All compounds were evaluated for anti-cancer activity at the National Cancer Institute (NCI).

Indexing (details)


Subject
Organic chemistry
Classification
0490: Organic chemistry
Identifier / keyword
Pure sciences; Anticancer; Celecoxib; Rofecoxib; Sydnone
Title
Syntheses and biological evaluation of potentially active sydnone analogues
Author
Dunkley, Christopher S.
Number of pages
241
Publication year
2005
Degree date
2005
School code
1379
Source
DAI-B 65/12, Dissertation Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
9780496922178, 0496922173
Advisor
Thoman, Charles J.
University/institution
University of the Sciences in Philadelphia
University location
United States -- Pennsylvania
Degree
Ph.D.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
3159369
ProQuest document ID
305350784
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/305350784
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