A series of mesoionic compounds (sydnones) were synthesized and evaluated for anticancer and anti-inflammatory activities. The first series of sydnones was designed as potential anti-cancer drugs based on two lead compounds developed by Grynberg et al. Another series of sydnones was designed as potential anti-inflammatory agents based on structural similarities between sydnones and rofecoxib and celecoxib. All compounds were evaluated for anti-cancer activity at the National Cancer Institute (NCI).
0490: Organic chemistry
Identifier / keyword
Pure sciences; Anticancer; Celecoxib; Rofecoxib; Sydnone
Syntheses and biological evaluation of potentially active sydnone analogues
Dunkley, Christopher S.
DAI-B 65/12, Dissertation Abstracts International
Place of publication
Country of publication
Thoman, Charles J.
University of the Sciences in Philadelphia
United States -- Pennsylvania
Dissertations & Theses
ProQuest document ID
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.