Progress toward the total synthesis of correolide: A potent and selective Kv1.3 potassium ion channel inhibitor
Correolide, a pentacylic nor-triterpenoid, isolated from Spachea correae is the most potent and selective small molecule inhibitor of the Kv1.3 channel. Selective blockage of the Kv1.3 ion channel results in a series of intracellular events that suppress T-cell proliferation and as a result the immune system. Suppression of T-cell proliferation is an attractive target for immunosuppresive therapies. Studies directed towards the total synthesis of correolide based on two diastereoselective Diels-Alder reactions and an intramolecular Heck reaction are described.
0379: Cellular biology