Abstract/Details

Progress toward the total synthesis of correolide: A potent and selective Kv1.3 potassium ion channel inhibitor


2006 2006

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Abstract (summary)

Correolide, a pentacylic nor-triterpenoid, isolated from Spachea correae is the most potent and selective small molecule inhibitor of the Kv1.3 channel. Selective blockage of the Kv1.3 ion channel results in a series of intracellular events that suppress T-cell proliferation and as a result the immune system. Suppression of T-cell proliferation is an attractive target for immunosuppresive therapies. Studies directed towards the total synthesis of correolide based on two diastereoselective Diels-Alder reactions and an intramolecular Heck reaction are described.

Indexing (details)


Subject
Organic chemistry;
Immunology;
Cellular biology
Classification
0490: Organic chemistry
0982: Immunology
0379: Cellular biology
Identifier / keyword
Health and environmental sciences; Pure sciences; Biological sciences; Correolide; Immunosuppression; Kv1.3; Potassium ion channel; Potassium ion channels; Spachea correae; T cell proliferation
Title
Progress toward the total synthesis of correolide: A potent and selective Kv1.3 potassium ion channel inhibitor
Author
Roth, Joshua John
Number of pages
138
Publication year
2006
Degree date
2006
School code
0030
Source
DAI-B 67/04, Dissertation Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
9780542646287, 0542646285
Advisor
Chamberlin, A. Richard
University/institution
University of California, Irvine
University location
United States -- California
Degree
Ph.D.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
3214081
ProQuest document ID
305374140
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/305374140
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