Abstract/Details

The interface between signaling, chromatin, and transcription


2005 2005

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Abstract (summary)

DNA is packaged in the nucleus of a cell into chromatin. As chromatin blocks the accessibility of cis regulatory elements, it can inhibit cellular processes which utilize DNA as a substrate including transcription, replication, DNA damage repair, and recombination. To contend with repressive chromatin, cells utilize remodeling complexes which mobilize nucleosomes and allow factor accessibility. Remodeling complexes require the cooperative activity of individual protein subunits to achieve maximum specificity and full function. To gain further insight into the specific functions of chromatin remodeling complexes, we study the ATP-dependent chromatin remodeling complex RSC (Remodels the Structure of Chromatin) in Saccharomyces cerevisiae. This work describes the characterization of two RSC subunits, Rsc7 and Rsc14, and the identification of a yeast-specific functional module in RSC. This work serves to broaden our understanding of RSC function as it strengthens/identifies links between RSC and many cellular processes. In a separate study, we examine the transcriptional regulation of RNA polymerase III genes by Maf1. This work provides important insight into Maf1 dephosphorylation as a switch for regulating repressing RNA polymerase III genes.

Indexing (details)


Subject
Molecular biology;
Genetics
Classification
0307: Molecular biology
0369: Genetics
Identifier / keyword
Biological sciences; Chromatin; Dephosphorylation; Maf1; RNA polymerase III; RSC subunits
Title
The interface between signaling, chromatin, and transcription
Author
Wilson, Boris Greer
Number of pages
176
Publication year
2005
Degree date
2005
School code
0240
Source
DAI-B 66/09, Dissertation Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
9780542341694, 0542341697
Advisor
Cairns, Brad
University/institution
The University of Utah
University location
United States -- Utah
Degree
Ph.D.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
3190695
ProQuest document ID
305398424
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/305398424
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