Abstract/Details

A *likelihood model of gene family evolution


2005 2005

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Abstract (summary)

The duplication of genes is a source of new genes, and thus can be of great interest. This thesis presents a simple model of gene duplication and gene loss, and a method by which the probability of a gene phylogeny can be computed for particular rates of these processes. This allows the likelihood of duplication and loss rates for a particular gene phylogeny to be determined. Using such calculations, I have examined the ability to estimate duplication and loss for a variety of different types of gene phylogenies.

Genetic data do not specify a single gene phylogeny with certainty. By integrating over many possible gene phylogenies via Markov chain Monte Carlo methods, uncertainty in the gene phylogeny is allowed. I have written a computer program to perform this calculation for DNA sequence data. With this, I have examined sources of variance in the estimation of gene duplication and loss rates.

Indexing (details)


Subject
Genetics;
Biostatistics
Classification
0369: Genetics
0308: Biostatistics
Identifier / keyword
Biological sciences; Gene duplication; Gene family; Likelihood; Markov chain Monte Carlo
Title
A *likelihood model of gene family evolution
Author
Dubb, Lindsey
Number of pages
127
Publication year
2005
Degree date
2005
School code
0250
Source
DAI-B 66/12, Dissertation Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
9780542442438, 0542442434
Advisor
Felsenstein, Joseph
University/institution
University of Washington
University location
United States -- Washington
Degree
Ph.D.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
3198780
ProQuest document ID
305422262
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/305422262
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