Abstract/Details

Molecular motor-based models of random intermittent search in dendrites


2010 2010

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Abstract (summary)

A key component in the cellular mechanisms underlying learning and memory involves the distribution and delivery of mRNA to synaptic sites in dendrites. A minimal three-state random intermittent search model of motor-driven mRNA transport is developed to explore the question of why motor-driven mRNA are observed moving bidirectionally. The model is analyzed by computing the probability an mRNA is delivered to a synaptic target and the average delivery time (MFPT). It is found that if the branched geometry of the dendrite is ignored, a purely unidirectional transport strategy will result in the smallest MFPT at any given delivery probability. The branched geometry of the dendrite is then incorporated into the model, and it is shown that a phase transition exists for a critical delivery probability where bidirectional strategies improve the corresponding MFPT. To further explore the impact of motor-driven transport behavior on mRNA delivery, the three-state model is extended to include a detailed, biophysical model of a multimotor complex coordinated through a tug-of-war. The model is analyzed to explore how various measurable, physical quantities, such as adenosine triphosphate, can be tuned to optimize cargo delivery.

Indexing (details)


Subject
Mathematics;
Neurobiology;
Biophysics
Classification
0405: Mathematics
0421: Neurobiology
0786: Biophysics
Identifier / keyword
Pure sciences; Biological sciences; Intracellular transport; Jump velocity; Molecular motors; Random search; mRNA transport
Title
Molecular motor-based models of random intermittent search in dendrites
Author
Newby, Jay
Number of pages
163
Publication year
2010
Degree date
2010
School code
0240
Source
DAI-B 71/09, Dissertation Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
9781124127729
Advisor
Bressloff, Paul C.
Committee member
Adler, Fred; Fogelson, Aaron; Jorgensen, Eric; Keener, James P.
University/institution
The University of Utah
Department
Mathematics
University location
United States -- Utah
Degree
Ph.D.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
3412992
ProQuest document ID
746479069
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/746479069
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