Abstract/Details

Anatomical evidence for cerebellar and reticular activating system involvement in adults with Attention-Deficit/Hyperactivity Disorder


2010 2010

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Abstract (summary)

Adult Attention-Deficit/Hyperactivity Disorder (ADHD) has been linked to impairments in attention, executive functioning, academic achievement, social relationships, and employment (Barkley, 1998). Functional brain imaging and neuropsychological assessment are becoming increasingly utilized for examining brain systems involved in ADHD. The current study examined functional differences in regional cerebral blood flow (rCBF) in three sample populations, adults with ADHD, adults with ADHD and Generalized Anxiety Disorder (GAD) comorbidity, and normal controls, while undergoing a concentration task (i.e., Continuous Performance Test). During the concentration task, there was significantly lower rCBF activity in the cerebellum, brainstem, and left frontal lobe for both ADHD and ADHD/GAD groups compared to controls. During rest, there was significantly lower rCBF in the bilateral medulla, pons, cingulate gyms, and cerebellum among ADHD groups than normal controls. Results from the continuous performance test indicated abnormal results in both ADHD groups compared to the normal group. Results suggest that the etiology for ADHD in adults with or without co-morbidity of GAD may involve deficits in the reticular activating system and sub-structures of the cerebellum.

Indexing (details)


Subject
Mental health;
Psychobiology;
Medical imaging;
Clinical psychology
Classification
0347: Mental health
0349: Psychobiology
0574: Medical imaging
0622: Clinical psychology
Identifier / keyword
Health and environmental sciences; Psychology; Attention deficit hyperactivity disorder; Blood flow; Cerebellum
Title
Anatomical evidence for cerebellar and reticular activating system involvement in adults with Attention-Deficit/Hyperactivity Disorder
Author
Ortiz, Tony
Number of pages
45
Publication year
2010
Degree date
2010
School code
1436
Source
DAI-B 71/09, Dissertation Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
9781124195858
Advisor
Bloch, Ellen
University/institution
Alliant International University, Los Angeles
University location
United States -- California
Degree
Ph.D.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
3421120
ProQuest document ID
750856306
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/750856306
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