Abstract/Details

Evolution of multigene families expressed during <i>Drosophila melanogaster</i> embryogenesis


2010 2010

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Abstract (summary)

Elucidating the evolution of embryonically expressed Drosophila melanogaster multigene families is crucial to a better understanding of metazoan development. These multigene families include essential components of various signal transduction pathways mandatory for proper embryogenesis. Two of these highly conserved pathways are the Wg/Wnt and TGF-beta pathways. In a molecular context, the evolutionary history of the Wg/Wnt pathway was elucidated and compared to the TGF-beta pathway. Whereas the TGF-beta pathway is characterized by many ancient gene duplications, analyses of the Wg/Wnt pathway revealed evidence for a number of gene duplication events unique to chordates. Further, differences in their receptor and signal transducer posttranslational modification regimes were found.

In a spatiotemporal context, the expression patterns of many additional multigene families expressed during D. melanogaster embryogenesis were also analyzed. To better study and quantify changes in gene expression, FlyExpress Release 4, an online resource containing the only digital library of standardized D. melanogaster embryos and computational tools for comparative expression pattern analysis, was developed. The FlyExpress resource was used to investigate the expression divergence of paralogous genes transcribed during D. melanogaster embryogenesis. Pairwise comparisons revealed a greater proportion of spatial compared to temporal divergence. Additionally, the contribution of spatial divergence varies across developmental stages, with duplicated genes showing an increasing refinement and divergence in spatial expression as development progresses. Paralogous D. melanogaster Wg/Wnt and TGF-beta pathway genes with in situ image data are largely consistent with overall expression trends found.

Indexing (details)


Subject
Molecular biology;
Genetics;
Evolution and Development
Classification
0307: Molecular biology
0369: Genetics
0412: Evolution and Development
Identifier / keyword
Biological sciences; Embryogenesis; Multigene families; TGF-beta
Title
Evolution of multigene families expressed during <i>Drosophila melanogaster</i> embryogenesis
Author
Konikoff, Charlotte E.
Number of pages
191
Publication year
2010
Degree date
2010
School code
0010
Source
DAI-B 71/10, Dissertation Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
9781124262123
Advisor
Newfeld, Stuart
University/institution
Arizona State University
University location
United States -- Arizona
Degree
Ph.D.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
3425816
ProQuest document ID
757227969
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/757227969
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