Abstract/Details

CB1 receptor activity modulates responses in the forced swim test and open field test paradigms


2010 2010

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Abstract (summary)

Cannabinoid type I (CB1) receptor activation in the forced swim test (FST) and on locomotor activity (LMA) was examined by manipulating the endogenous agonist anandamide (AEA). AEA modifier URB597 prevents AEA metabolism and AM404 inhibits the reuptake of AEA in post synaptic neurons.

Antidepressant-like behavior was measured using time spent immobile (sec) in the FST, and distance traveled (cm), average velocity (cm/sec), entries into the center zone (#), and time spent in the center zone (min) in the open field test. LMA before (Pre-FST1), immediately after (Post-FST1), and a week after the FST (LMA-FST1) were measured.

Time spent immobile decreased with desipramine (DMI; 10 mg/kg), URB597 (1.0 and 3.2 mg/kg), and AM404 (1.0 mg/kg). Although 1.0 mg/kg of URB597 and AM404 reduced time spent immobile, distance traveled was not impaired. Overall, the decreases in time spent immobile were not because of LMA solely, and URB597 and AM404 have antidepressant properties.

Indexing (details)


Subject
Neurosciences;
Behavioral psychology;
Pharmacology
Classification
0317: Neurosciences
0384: Behavioral psychology
0419: Pharmacology
Identifier / keyword
Health and environmental sciences; Psychology; Biological sciences; Acute forced swim test; Antidepressants; Cannabinoid type 1 receptor; Locomotion
Title
CB1 receptor activity modulates responses in the forced swim test and open field test paradigms
Author
Culmer, Tyechia L.
Number of pages
52
Publication year
2010
Degree date
2010
School code
0153
Source
MAI 49/02M, Masters Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
9781124323602
Advisor
Dykstra, Linda
Committee member
Crews, Fulton; Hodge, Clyde
University/institution
The University of North Carolina at Chapel Hill
Department
Pharmacology
University location
United States -- North Carolina
Degree
M.S.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
1482921
ProQuest document ID
815249348
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/815249348
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