Abstract/Details

Genetic regulation of the generation of neuronal diversity in the developing mammalian basal forebrain


2010 2010

Other formats: Order a copy

Abstract (summary)

The forebrain is the structure that is most implicated in complex mammalian behaviors: consciousness, reason, language, memory, and emotionality are all the result of cellular and molecular processes in this region of the brain. The telencephalon is the embryonic precursor to the forebrain; through several developmental mechanisms, including the patterning of progenitor domains, and the proliferation, migration, and specification of neuronal subtypes, the telencephalon gives rise to a complex and highly ordered functional network made up of a diversity of neuronal subtypes that process and integrate information and control behavior. The molecular mechanisms by which this brain region is formed during embryonic development are still being explored. We sought to examine the mechanisms used in the development of forebrain neuronal diversity by examining several important developmental questions using a combination of genetic fate-mapping, mutagenesis, cell birth-dating, migration assays, immunohistochemistry, and electrophysiology. We examined the genetic regulation of border formation in the telencephalon, and the impact that the correct patterning of this structure has on the fate of cells in the forebrain. We found that genetic regulation of border formation is critical for dorsal ventral patterning and is necessary for the correct generation of excitatory and inhibitory neuronal subpopulations in the amygdala and olfactory bulb. We also examined the importance of embryonic development on the fate of cells in the postnatal forebrain, and found that the generation of neuronal diversity in the amygdala, striatum, and olfactory bulb is regulated by interactions between several biological processes, including the origin and timing of progenitor cell birth, combinatorial codes of transcription factor expression, and diverse migratory pathways.

Indexing (details)


Subject
Neurosciences;
Developmental biology
Classification
0317: Neurosciences
0758: Developmental biology
Identifier / keyword
Health and environmental sciences; Biological sciences; Embryonic development; Forebrain; Gene regulation; Neuronal fate; Telencephalon
Title
Genetic regulation of the generation of neuronal diversity in the developing mammalian basal forebrain
Author
Cocas, Laura A.
Number of pages
204
Publication year
2010
Degree date
2010
School code
0076
Source
DAI-B 72/01, Dissertation Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
9781124342238
Advisor
Corbin, Joshua
Committee member
Casey, Elena; Haydar, Tarik; Maria, Donoghue; Pak, Daniel; Vicini, Stefano
University/institution
Georgetown University
Department
Neuroscience
University location
United States -- District of Columbia
Degree
Ph.D.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
3428175
ProQuest document ID
817554215
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/817554215/abstract
Access the complete full text

You can get the full text of this document if it is part of your institution's ProQuest subscription.

Try one of the following:

  • Connect to ProQuest through your library network and search for the document from there.
  • Request the document from your library.
  • Go to the ProQuest login page and enter a ProQuest or My Research username / password.