Abstract/Details

Racial differences in heart failure with preserved ejection fraction in the ambulatory heart failure population


2010 2010

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Abstract (summary)

Racial differences in heart failure with preserved ejection fraction (HFpEF) have rarely been studied in an ambulatory, financially "equal access" cohort, although the majority of such patients are treated as outpatients.

Retrospective data was collected from 2,526 patients (2,240 Whites, 286 African American) with HFpEF treated at 153 VA clinics, as part of the VA External Peer Review Program (EPRP) between October 2000 and September 2002. Kaplan Meier curves (stratified by race) were created for time to first heart failure (HF) hospitalization, all cause hospitalization and death and Cox proportional multivariate regression models were constructed to evaluate the effect of race on these outcomes.

African American patients were younger (67.7 ± 11.3 vs. 71.2 ± 9.8 years; p < 0.001), had lower prevalence of atrial fibrillation (24.5 % vs. 37%; p <0.001), chronic obstructive pulmonary disease (23.4 % vs. 36.9%, p <0.001), but had higher blood pressure (systolic blood pressure > 120 mm Hg 77.6% vs. 67.8%; p < 0.01), glomerular filtration rate (67.9 ± 31.0 vs. 61.6 ± 22.6 mL/min/1.73 m2; p < 0.001), anemia (56.6% vs. 41.7%; p <0.001) as compared to whites. African Americans were found to have higher risk adjusted rate of HF hospitalization (HR 1.52, 95% CI 1.1 - 2.11; p = 0.01), with no difference in risk-adjusted all cause hospitalization (p = 0.80) and death (p= 0.21).

In a financially "equal access" setting of the VA, among ambulatory patients with HFpEF, African Americans have similar rates of mortality and all cause hospitalization but have an increased risk of HF hospitalizations compared to whites.

Indexing (details)


Subject
Medicine;
Public health;
Epidemiology
Classification
0564: Medicine
0573: Public health
0766: Epidemiology
Identifier / keyword
Health and environmental sciences, Ambulatory, Heart failure, Hospitalization, Mortality, Preserved ejection fraction, Race
Title
Racial differences in heart failure with preserved ejection fraction in the ambulatory heart failure population
Author
Basra, Sukhdeep Singh
Number of pages
40
Publication year
2010
Degree date
2010
School code
0219
Source
MAI 49/02M, Masters Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
9781124349039
Advisor
Bressler, Jan
Committee member
Batholomew, Leona K.; Deswal, Anita
University/institution
The University of Texas School of Public Health
Department
Epidemiology & Disease Control
University location
United States -- Texas
Degree
M.P.H.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
1483150
ProQuest document ID
818751366
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/818751366
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