Abstract/Details

Magnetically Vectored Nanocapsules for Tumor Penetration and Remotely Switchable On-Demand Drug Release


2010 2010

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Abstract (summary)

Hollow-sphere nanocapsules containing intentionally trapped magnetic nanoparticles and defined anticancer drugs provide a powerful magnetic vector under moderate gradient magnetic fields, and enable the nanocapsules to penetrate into the midst of tumors and allow a controlled on-off switchable release of the anticancer drug cargo by remotely applied Radio Frequency (RF) magnetic field. This imageable smart drug delivery system is compact because the drug molecules and magnetic nanoparticles can all be self-contained within 80~150 nm capsules. In vitro as well as in vivo results indicate that the nanocapsules are effective in reducing tumor cell growth.

In Chapter 1, the concept of Drug Delivery Systems (DDSs) and the impact of nanotechnology on Drug Delivery Systems were introduced. Triggered drug release using magnetothermally-responsive nanomaterials, magnetic nanoparticles for nanomedicine, and ordered mesoporous materials in the context of Drug Delivery System were discussed. In Chapter 2, creation of remotely controllable, On-Off switchable drug release methodology was described. In this thesis work, triggerable nanocapsules which contain magnetic nanoparticles responsive to external radio frequency (RF) magnetic field have been successfully created. This is in contrast to the regular hollow nanospheres for slow passive release of drugs. The new nanocapsule material consists of bio-inert, bio-compatible or bio-degradable material that we can be selected from a variety of materials depending on specific medical applications. In Chapter 3, study and utilization of magnetic vector for guided tumor penetration was discussed. In the presence of a moderate gradient magnetic field, a powerful magnetic vector is created that allows these nanocapsules to cross cell membranes or blood-tissue barriers and penetrate into the midst of tumors, thus overcoming the well-known problem of limited access of anti-cancer drugs to cancer cells in the interior of a tumor tissue. In Chapter 4, potential applications to Blood-Brain-Barrier (BBB) crossing and other therapeutics was described. In Chapter 5, the study was summarized and concluded.

Indexing (details)


Subject
Pharmacy sciences;
Nanotechnology;
Materials science
Classification
0491: Pharmacy sciences
0652: Nanotechnology
0794: Materials science
Identifier / keyword
Applied sciences; Pure sciences; Anti-cancer; Drug delivery; Magnetic vectors; Nanocapsules; Switchable on-demanding; Tumor penetration
Title
Magnetically Vectored Nanocapsules for Tumor Penetration and Remotely Switchable On-Demand Drug Release
Author
Kong, Seong Deok
Number of pages
117
Publication year
2010
Degree date
2010
School code
0033
Source
DAI-B 72/02, Dissertation Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
9781124362823
Advisor
Jin, Sungho
Committee member
Bandaru, Prabhakar; Lubarda, Vlado A.; Meyers, Marc; Qiao, Yu
University/institution
University of California, San Diego
Department
Materials Sci and Engineering
University location
United States -- California
Degree
Ph.D.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
3432381
ProQuest document ID
821439083
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/821439083
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