Abstract/Details

White Matter Integrity in Individuals at Risk for Alzheimer's Disease: A Diffusion Tensor Imaging Study


2011 2011

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Abstract (summary)

Diffusion Tensor Imaging (DTI) studies have confirmed changes in white matter integrity in normal aging which appear more pronounced in both Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD). Few DTI studies have examined asymptomatic individuals at risk for AD, and most have focused solely on changes in fractional anisotropy (FA). In this study, we compared three other DTI indices, mean diffusivity (MD), axial diffusivity (DA), and radial diffusivity (DR) in addition to FA, in cognitively intact older participants who differed on AD risk factors (APOE 4 allele and family history). The At-Risk group had a positive family history of AD and one or both Apolipoprotein (APOE) ϵ4 alleles (n = 29) and the No-Risk group had neither risk factor (n = 29). There were no group differences on age, education, sex, or cognitive status. Groups were compared on four DTI indices, using both tract-based spatial statistics (TBSS) and region of interest (ROI) approaches. The At-Risk group showed widespread, bilateral increase in DA, and to a lesser extent in DR and MD, relative to the No-Risk group. In contrast, no group differences were observed in FA. Good correspondence was observed between the ROI and TBSS analyses. FA was most correlated with measures of memory, while radial diffusivity and especially axial diffusivity showed less relation to cognitive variables. These findings suggest that DTI indices of diffusivity, especially in the axial direction, may be a useful biomarker in identifying older persons at risk for AD. Longitudinal studies are needed to determine if these DTI indices can play a role in the prediction of future cognitive decline in asymptomatic individuals.

Indexing (details)


Subject
Neurosciences;
Psychobiology;
Clinical psychology
Classification
0317: Neurosciences
0349: Psychobiology
0622: Clinical psychology
Identifier / keyword
Psychology; Biological sciences; Alzheimer's disease; Diffusion tensor imaging; White matter
Title
White Matter Integrity in Individuals at Risk for Alzheimer's Disease: A Diffusion Tensor Imaging Study
Author
Lancaster, Melissa A.
Number of pages
69
Publication year
2011
Degree date
2011
School code
1489
Source
MAI 49/03M, Masters Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
9781124446905
Advisor
Seidenberg, Michael
Committee member
Kessler, Kenneth; Rao, Stephen
University/institution
Rosalind Franklin University of Medicine and Science
Department
Psychology
University location
United States -- Illinois
Degree
M.S.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
1488371
ProQuest document ID
850514677
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/850514677
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