Abstract/Details

An experimental model of human aortic dissection


2011 2011

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Abstract (summary)

Vascular diseases such as aortic dissections, aneurysms and stenosis are becoming frequent disorders in the industrialized world, and aortic diseases constitute an emerging share of these. An acute aortic dissection of the ascending aorta has an increasing mortality rate of 1% to 2% per hour after symptom onset. Determining whether an aortic dissection is at risk for rupture is not straightforward, and a better understanding of the role of thrombus, vessel geometry and wall components, entry tears, and other features of the diseased aorta is needed.

The focus of this dissertation is to build an experimental bench top model of an aortic dissection which provides a fundamental knowledge of the flow characteristics and flap behavior under various physiological conditions. This model may help to emulate the forces and appearance of a dissection and explain the flow/pressure events that affect the stability or progression of a dissection. The operation of such a model will permit ranking the variables that determine the evolution of a dissection towards aneurysm or rupture. The mechanical properties of the polydimethylsiloxane (PDMS) material used to create experimental models of aortic dissections were investigated in the range of physiological parameters. This research may also be used as a benchmark to validate numerical models of aortic dissection. It also paves the road for researchers in the area of imaging to determine the elastic modulus of a living in-vivo arterial wall based on dynamic DICOM files in a non-invasive manner using high resolution CT scans.

Indexing (details)


Subject
Biomedical engineering;
Medical imaging;
Biomechanics;
Studies
Classification
0541: Biomedical engineering
0574: Medical imaging
0648: Biomechanics
Identifier / keyword
Health and environmental sciences; Applied sciences; Biological sciences; Acute dissection; Aorta; Aortic dissection; Chronic dissection; Vascular diseases
Title
An experimental model of human aortic dissection
Author
Schlicht, Martin S., Jr.
Number of pages
127
Publication year
2011
Degree date
2011
School code
0127
Source
DAI-B 72/08, Dissertation Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
9781124684765
Advisor
Berguer, Ramon; Bull, Joseph L.
University/institution
University of Michigan
University location
United States -- Michigan
Degree
Ph.D.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
3458942
ProQuest document ID
873944699
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/873944699
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