Abstract/Details

Sex differences in the relationship of polyunsaturated fatty acids and noninvasive imaging measures of subclinical cardiovascular disease


2011 2011

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Abstract (summary)

Background. The association between plasma phospholipid omega-6 levels and cardiovascular disease (CVD) morbidity and mortality is unclear, and discrepancy remains concerning the cardiovascular benefit of the omega-3 fatty acid alpha-linolenic acid (ALA).

Objective. To determine the associations between plasma phospholipid omega-6 (arachidonic acid (AA), linoleic acid (LA)) and omega-3 levels (eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), ALA) with cardiac magnetic resonance imaging (CMR) measures of left ventricular and aortic dysfunction.

Design. Cross-sectional associations of plasma phospholipid levels with CMR measures of LV mass, LV volumes, ejection fraction, stroke volume, and aortic distensibility were investigated in 1,274 adults from four racial/ethnic groups, aged 45–84 years, free of clinical CVD who underwent CMR at baseline examination.

Results. Results of multivariate analysis adjusted for age, race/ethnicity, gender, BMI, smoking, education, field center, physical activity, systolic blood pressure, total:HDL cholesterol, and total energy intake, showed no statistically significant associations of plasma phospholipid omega-6 or omega-3 levels with CMR measures at the a priori-specified level of p <0.01. However, in women, plasma phospholipid DHA was positively associated with LV mass (beta = 1.89, p = 0.02; p interaction = 0.003). Conversely, a trend for a positive association between plasma phospholipid DHA and ejection fraction was noted in men (beta = 0.009, p = 0.05; p interaction = 0.03).

Conclusions. Results suggest the association between plasma phospholipid DHA and CMR measures of LV mass and ejection fraction vary by gender. Additional research is warranted to clarify the effects of omega-3 fatty acids on cardiac structure and function in women versus men.

Indexing (details)


Subject
Nutrition;
Medical imaging
Classification
0570: Nutrition
0574: Medical imaging
Identifier / keyword
Health and environmental sciences; Cardiac MRI; Cardiovascular disease; Fish; Polyunsaturated fatty acids; Sex differences
Title
Sex differences in the relationship of polyunsaturated fatty acids and noninvasive imaging measures of subclinical cardiovascular disease
Author
Anderson, Jennifer S.
Number of pages
93
Publication year
2011
Degree date
2011
School code
0248
Source
MAI 49/06M, Masters Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
9781124695099
Advisor
Herrington, David M.
Committee member
Bell, Ronny; Hundley, W. Gregory; Morgan, Timothy; Vitolins, Mara
University/institution
Wake Forest University
Department
Clinical and Population Translational Sciences
University location
United States -- North Carolina
Degree
M.S.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
1494542
ProQuest document ID
875565567
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/875565567
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