Abstract/Details

Design and synthesis of a new class of self-cross-linked polymer nanogels


2011 2011

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Abstract (summary)

The design and engineering of nanoscopic drug delivery vehicles that stably encapsulate lipophilic drug molecules, transport their loaded cargo to specific target sites, and release their payload in a controlled manner are of great interest in therapeutic applications, especially for cancer chemotherapy. This dissertation focuses on chemically cross-linked, water-soluble polymer nanoparticles, termed nanogels, which constitute a promising scaffold and offer the potential to circumvent encapsulation stability issues. A facile synthetic method for a new class of self-cross-linked polymer nanogels, synthesized by an intra/intermolecular disulfide cross-linking reaction in aqueous media, is described here. This simple emulsion-free method affords noncovalent lipophilic guest encapsulation and surface functionalization that may allow for targeted delivery. The encapsulation stability of lipophilic molecules sequestered within these nanoscopic containers is evaluated by a fluorescent resonance energy transfer (FRET) based method developed by our research group. We demonstrate that the encapsulation stability of noncovalently encapsulated guest molecules in disulfide cross-linked polymer nanogels can be tuned and that guest release can be achieved in response to a biologically relevant stimulus (GSH). In addition, varied hydrophobicity in the self-cross-linked nanogels affects the lipophilic loading capacity and encapsulation stability. We reveal that optimal loading capacity is limited by encapsulation stability, where over-loading of lipophilic molecules in the nanoscopic containers may cause undesirable leakage and severely compromise the viability of such systems for drug delivery and other biological applications.

Indexing (details)


Subject
Organic chemistry;
Pharmacy sciences;
Polymer chemistry;
Nanotechnology
Classification
0490: Organic chemistry
0491: Pharmacy sciences
0495: Polymer chemistry
0652: Nanotechnology
Identifier / keyword
Applied sciences; Pure sciences; Drug delivery; Encapsulation stability; Nanogels/naoparticles; Self-cross-linked polymer nanogels
Title
Design and synthesis of a new class of self-cross-linked polymer nanogels
Author
Jiwpanich, Siriporn
Number of pages
144
Publication year
2011
Degree date
2011
School code
0118
Source
DAI-B 72/10, Dissertation Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
9781124766782
Advisor
Thayumanavan, Sankaran
Committee member
Martin, Craig T.; Roberts, Susan C.; Vachet, Richard W.
University/institution
University of Massachusetts Amherst
Department
Chemistry
University location
United States -- Massachusetts
Degree
Ph.D.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
3465020
ProQuest document ID
883121061
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/883121061
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