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Copyright Sociedade Brasileira de Medicina Tropical Sep/Oct 2005

Abstract

Comparison of the presence of Candida yeasts in the buccal cavity of children without and with Down's syndrome showed a statistically significant difference in the case of children that were affected by this chromosomopathy, rendering them more predisposed to buccal candidiasis, probably due to anatomicophysiologic alterations of the mouth resulting from trisomy of chromosome 21. Constant recurrence of buccal candidiasis in children with this chromosomal alteration lead to the search for a possible therapeutic alternative. Seeking to determine the antifungal activity of Streptomyces sp isolated from various Brazilian soils, 5 strains have been tested for Candida albicans isolated from the buccal cavity of children with Down's syndrome. It was observed that the isolate presented a diversity in the size of the halos (9-31mm in diameter) of growth inhibition of the yeasts, suggesting a possible use as a therapeutic antifungal.

Details

Title
Candida albicans isolated from buccal cavity of children with Down's syndrome: occurrence and growth inhibition by Streptomyces sp
Author
Vieira, José Daniel Gonçalves; Ribeiro, Evandro Leão; Campos, Cerise de Castro; Pimenta, Fabiana Cristina; Toledo, Orlando Ayrton de; Nagato, Gustavo Morais; Souza, Niwmar Alves de; Ferreira, Wesley Magno; Cardoso, Cléver Gomes; Dias, Sueli Meira da Silva; Araújo, Júnior César Aparício de; Zatta, Daniel Teles; Santos, Juliana de Sousa dos
Section
Articles
Publication year
2005
Publication date
Sep/Oct 2005
Publisher
Sociedade Brasileira de Medicina Tropical
ISSN
00378682
e-ISSN
16789849
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1449161664
Copyright
Copyright Sociedade Brasileira de Medicina Tropical Sep/Oct 2005