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Citation/Abstract

Breast cancer risk with aromatase inhibition and phytoestrogen-free diet


2011 2011

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Abstract (summary)


In this thesis a mouse model was used to examine the effect of pubertal estrogen inhibition and a phytoestrogen-free diet on the development of mammary glands. The study question was does treatment with aromatase inhibitor during puberty increase susceptibility to breast cancer among cohorts that consumed a diet free of phytoestrogens. The study design consisted of a cohort of mice treated with aromatase inhibitor, letrozole, during puberty and a vehicular group that was used as a control. Both groups were fed a diet free of phytoestrogens from the time of weaning until sacrifice during adulthood. The study aimed to assess mammary gland development in terms of breast cancer risk. The methods employed in this research included morphological and histological analysis of mammary glands, as well as estradiol, RNA and protein analysis. The main finding of the study was that mice exposed to aromatase inhibitor during puberty developed mammary glands with specific characteristics suggestive of vulnerability to oncogenesis such as increased lateral branching, increased number of glands, increase ductal hyperplasia, and diminished expression of TGFβ and p27 protein levels. The conclusions suggest that puberty is a critical period in which the mammary gland is susceptible to environmental threats that may result in deleterious epigenetic effects leading to an increased breast cancer risk in adulthood. This study has several public health implications; the most significant is that environmental threats during puberty may result in adverse mammary gland development and that phytoestrogen sources in the diet are necessary for normal maturation of the mammary glands.

Indexing (details)


Subject
Public health;
Oncology
Classification
0573: Public health
0992: Oncology
Identifier / keyword
Health and environmental sciences, Aromatase, Breast cancer, Phytoestrogen
Title
Breast cancer risk with aromatase inhibition and phytoestrogen-free diet
Author
Turner, Kelly
Number of pages
40
Publication year
2011
Degree date
2011
School code
0219
Source
MAI 50/05, Oct 2012
Place of publication
Ann Arbor
Country of publication
United States
ISBN
9781267239952
Advisor
Perkins, Jimmy, Gimeno, David
Committee member
Kirma, Nameer
University/institution
The University of Texas School of Public Health
Department
Epidemiology & Disease Control
University location
United States -- Texas
Degree
M.P.H.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
1507197
ProQuest document ID
936783256
Copyright
Copyright ProQuest, UMI Dissertations Publishing 2011
Document URL
http://search.proquest.com/docview/936783256