Abstract/Details

Is there an association between choline/betaine dietary intake and lung cancer?


2011 2011

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Abstract (summary)

Choline and betaine are important methyl donors that contribute to protein and phospholipid synthesis and DNA methylation. They can either be obtained through diet or synthesized de novo. Evidence from human and animal research indicates that choline metabolic pathways may be activated during a variety of diseases, including cancer. Studies have been conducted to investigate the role of dietary intake of choline and betaine on cancers, but results vary among studies by cancer types, and no such study had been conducted for lung cancer. We conducted a case-control study to explore the association between choline and betaine dietary intake and lung cancer. A total of 2807 cases and 2919 controls were included in the study. After adjusting for total calorie intake, age, sex, race and smoking status, multivariable logistic regression analysis revealed a significant negative association between choline/betaine intake and lung cancer. Specifically, we observed that higher choline intake was associated with reduced lung cancer odds, and the association did not differ significantly by smoking status. A similar negative trend was observed in the association between betaine intake and lung cancer after adjusting for total calorie intake, age, sex, smoking status, race, and pack-years of smoking. However, this association was strongly affected by smoking. No significant association was observed with increased betaine intake and lung cancer among never smokers, but higher betaine intake was strongly associated with reduced lung cancer odds among smokers, and lower odds ratios were observed among current smokers than among former smokers. Our results suggest that high intake of choline may be protective for lung cancer independent of smoking status, while high betaine intake may mitigate the adverse effect of smoking on lung cancer, and help prevent lung cancer among smokers.

Indexing (details)


Subject
Biostatistics;
Nutrition;
Epidemiology;
Oncology
Classification
0308: Biostatistics
0570: Nutrition
0766: Epidemiology
0992: Oncology
Identifier / keyword
Health and environmental sciences; Biological sciences; Association; Betaine; Choline; Intake; Lung cancer; Smoking
Title
Is there an association between choline/betaine dietary intake and lung cancer?
Author
Ying, Jun
Number of pages
129
Publication year
2011
Degree date
2011
School code
0219
Source
MAI 50/05M, Masters Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
9781267242877
Advisor
Rahbar, Mohammad H.
Committee member
Hallman, Michael; Kapadia, Asha
University/institution
The University of Texas School of Public Health
Department
Biostatistics
University location
United States -- Texas
Degree
M.S.
Source type
Dissertations & Theses
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
1507234
ProQuest document ID
943779586
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
http://search.proquest.com/docview/943779586
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