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Copyright © 2013 Daniel Grenier. Daniel Grenier et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Porphyromonas gingivalissheds outer membrane vesicles that contain several virulence factors, including adhesins. In this study, we investigated the ability of P. gingivalisouter membrane vesicles to mediate the coaggregation and piggybacking of Treponema denticolaand Lachnoanaerobaculum saburreum. Marked coaggregation between T. denticolaand L. saburreumoccurred in the presence of P. gingivalisouter membrane vesicles. Sucrose was an effective chemoattractant for the motile species T. denticola. The addition of outer membrane vesicles to a mixture of T. denticolaand L. saburreumsignificantly increased the number of nonmotile bacteria that migrated into a sucrose-filled capillary tube immersed in the bacterial mixture. Under optimal conditions, the number of nonmotile L. saburreumin the capillary tube increased approximately 5-fold, whereas no increase occurred when boiled vesicles were used. This study showed that P. gingivalisouter membrane vesicles mediate coaggregation between T. denticolaand L. saburreumand that nonmotile bacteria can be translocated by piggybacking on spirochetes.

Details

Title
Porphyromonas gingivalisOuter Membrane Vesicles Mediate Coaggregation and Piggybacking of Treponema denticolaand Lachnoanaerobaculum saburreum
Author
Grenier, Daniel
Publication year
2013
Publication date
2013
Publisher
Hindawi Limited
ISSN
16878728
e-ISSN
16878736
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1419984360
Copyright
Copyright © 2013 Daniel Grenier. Daniel Grenier et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.