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Antiandrogen Therapy in Recurrent Prostate Cancer
With a median follow-up of 13 years, a randomized comparison of radiotherapy with or without antiandrogen therapy in patients with a rising PSA level after prostatectomy showed that 2 years of antiandrogen therapy resulted in a significantly higher overall survival rate.
see Original Article, N Engl J Med 2017;376:417-428
Crisis Prevention in Sickle Cell Disease
In this yearlong trial involving patients with sickle cell disease, crizanlizumab, an antibody to P-selectin, was associated with a 45% lower rate of pain crises than placebo and a longer time to their onset. Adverse events included arthralgia, diarrhea, and pruritus.
see Original Article, N Engl J Med 2017;376:429-439
Comparing Ventricular Assist Systems for Heart Failure
In a randomized trial, 294 patients with advanced heart failure were assigned to receive either a new centrifugal-flow pump or an axial-flow pump. At 6 months, the centrifugal-flow pump was associated with better outcomes.
see Original Article, N Engl J Med 2017;376:440-450
Intrapericardial Left Ventricular Assist Device
In this trial, patients with advanced heart failure were assigned to an intrapericardial centrifugal-flow LVAD or an...