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KIT Inhibition by Imatinib in Severe Asthma
This proof-of-principle trial showed that imatinib treatment reduced mast-cell activation and improved airway responsiveness in patients with severe refractory asthma.
see Original Article, N Engl J Med 2017;376:1911-1920
Treating Eosinophilic Granulomatosis with Polyangiitis
Among participants with eosinophilic granulomatosis with polyangiitis, 32% had remission at weeks 36 and 48 when treated with mepolizumab, an anti–interleukin-5 monoclonal antibody, as compared with 3% of the participants in the placebo group.
see Original Article, N Engl J Med 2017;376:1921-1932
Evacetrapib in High-Risk Vascular Disease
In a randomized trial involving patients with high-risk vascular disease, the cholesteryl ester transfer protein inhibitor evacetrapib had favorable effects on established lipid biomarkers but was not associated with a lower rate of cardiovascular events than placebo.
see Original Article, N Engl J Med 2017;376:1933-1942
Exercise Training in Dieting Obese Older Adults
In a study of diet and several exercise modes to reverse frailty and prevent weight-loss–induced reduction in muscle and bone in obese older adults, weight loss plus combined aerobic and resistance exercise was the most effective method of improving functional status.
see Original Article, N Engl...