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Airway Mucin Concentration and Chronic Bronchitis
Chronic bronchitis is currently diagnosed by asking patients if they expectorate sputum on a regular basis. In this study, the concentration of mucin was higher in the induced sputum of patients with chronic bronchitis than in those who did not meet the case definition of the disorder.
see Original Article, N Engl J Med 2017;377:911-922
Tiotropium in Early-Stage COPD
Patients with early-stage COPD were assigned to usual care plus tiotropium or placebo. Tiotropium resulted in better FEV1 values. The annual decline in the prebronchodilator FEV1 was similar in the two groups, but a benefit from tiotropium was seen in postbronchodilator FEV1.
see Original Article, N Engl J Med 2017;377:923-935
Tezepelumab in Adults with Uncontrolled Asthma
Treatment with tezepelumab, a human monoclonal antibody specific for thymic stromal lymphopoietin, reduced exacerbation frequency among patients whose asthma remained uncontrolled with long-acting beta-agonists and medium-to-high doses of inhaled glucocorticoids.
see Original...