Content area
Abstract
It is well accepted that loading-induced fluid flow is one of the key factors in triggering bone modeling and remodelling processes through which bones maintain adequate bone mass and architecture. To develop a unique model to provide a more complete picture of fluid flow in bone, STARS, a CMG (Computer Modeling Group Ltd.) porous media fluid flow and mechanical displacement simulator designed for oil recovery applications, was implemented. Three models were constructed to run on STARS to study the effect of cyclical loading and diffusion on fluid flow and nutrient transport in cortical bone. These models included a mouse tibia model, based on a 2D μCT image, a human bone sample model based on a 3D μCT reconstruction and an idealized osteon model. The results revealed the sites of high and low fluid flow as well as tracer transport at the full bone and osteon levels.
