Abstract/Details

Histomorphometry of the elderly rib: A methodological approach with implications for biomechanics, function and fracture risk

Agnew, Amanda Marie.   The Ohio State University ProQuest Dissertations Publishing,  2011. 3476936.

Abstract (summary)

The purpose of this study is to characterize the variable microstructure of the elderly human rib in an attempt to elucidate its contributions to biomechanical adaptive responses and fragility. Histological sections were made from Basic Fuchsin stained bilateral 6th ribs from 10 elderly post-mortem human subjects (PMHS). Percent Porosity Area (% Po.Ar), mean Osteon Area (On.Ar), mean Crack Length (Cr.Le), Crack Density (Cr.Dn), and Crack Surface Density (Cr.S.Dn) were successfully quantified and analyzed. ANOVA results indicate that all variables show significant inter-individual variation, but no significant bilateral variation within individuals. Subject variation could contribute to differential individual fragility. Paired t-tests revealed cortex differences for these variables (most are significant) between compressive and tensile cortices in a presumed cyclic bending loading pattern in the rib. These findings can contribute to interpretations about loading history and mechanical adaptation as well as bone behavior prior to failure. A methodological investigation into microfracture data collection showed significant differences between a “total” dataset and a “sampled” dataset. Therefore, it is recommended that only microfracture data collected from the entire rib cortex be utilized in future studies until a more representative sampling method can be developed. This study should prompt investigators to incorporate a histological perspective into interpretations as to why and how bone failure may occur and what contributes to fracture risk in the elderly rib in both modern and past populations.

Indexing (details)


Subject
Morphology;
Physical anthropology;
Biomechanics
Classification
0287: Morphology
0327: Physical anthropology
0648: Biomechanics
Identifier / keyword
Social sciences; Biological sciences; Bone microstructure; Fracture risk
Title
Histomorphometry of the elderly rib: A methodological approach with implications for biomechanics, function and fracture risk
Author
Agnew, Amanda Marie
Number of pages
188
Degree date
2011
School code
0168
Source
DAI-A 81/1(E), Dissertation Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
978-1-124-90953-0
Advisor
Stout, Sam D.
University/institution
The Ohio State University
Department
Anthropology
University location
United States -- Ohio
Degree
Ph.D.
Source type
Dissertation or Thesis
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
3476936
ProQuest document ID
898360621
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
https://www.proquest.com/docview/898360621