Abstract/Details

Development of a Novel Measure of Three-Dimensional Bone Connectivity in a Mouse Tibia Fracture Model: Characterizing Torsional Strength and Stiffness Through Failure Surface Analysis

Wright, David.   University of Toronto (Canada) ProQuest Dissertations & Theses,  2011. MR76592.

Abstract (summary)

The high incidence of long bone fractures and appreciable rate of delayed and non-union (5-10%) necessitates the development of non-invasive tools to monitor healing progression. The objective of this study was to develop a novel μCT-based measure of three-dimensional bone connectivity and to compare its ability to assess fracture callus mechanical stability to previously described measures. Bone connectivity parameters local to the failure surface were found to significantly correlate with mechanical stability, and proved superior to previously developed measures of torsional rigidity. Visualization of the failure surfaces demonstrated a consistent failure pattern indicative of the applied torsional loading, however the locations of the failure surfaces showed varying levels of fracture callus involvement. The results of this proof of concept work indicate the potential utility of bone connectivity analysis in non-invasive assessment of fracture callus stability.

Indexing (details)


Subject
Biomedical engineering
Classification
0541: Biomedical engineering
Identifier / keyword
Applied sciences; Fracture healing; Strength
Title
Development of a Novel Measure of Three-Dimensional Bone Connectivity in a Mouse Tibia Fracture Model: Characterizing Torsional Strength and Stiffness Through Failure Surface Analysis
Author
Wright, David
Number of pages
70
Degree date
2011
School code
0779
Source
MAI 50/04M, Masters Abstracts International
ISBN
978-0-494-76592-0
Advisor
Whyne, Cari; Nam, Diane
University/institution
University of Toronto (Canada)
Department
Biomedical Engineering
University location
Canada -- Ontario, CA
Degree
M.A.Sc.
Source type
Dissertation or Thesis
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
MR76592
ProQuest document ID
926958486
Copyright
Database copyright ProQuest LLC; ProQuest does not claim copyright in the individual underlying works.
Document URL
https://www.proquest.com/docview/926958486