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Copyright Sociedade Brasileira de Medicina Tropical Jan/Feb 2010

Abstract

INTRODUCTION: Hyporetinolemia is an independent prognostic factor in AIDS patients. Inflammatory activity causes a reduction in the serum levels of this nutrient in the general population. However, there are no studies assessing the impact of inflammatory activity on the serum retinol level in AIDS patients. METHODS: A cross-sectional assessment was conducted on 41 patients hospitalized due to AIDS complications. Inflammatory markers (C-reactive protein and tumor necrosis factor-alpha) and serum retinol and retinol binding protein concentrations were quantified. RESULTS: Despite the low (14.6%) prevalence of hyporetinolemia, a significant negative correlation was observed between the inflammatory markers and the serum retinol and retinol binding protein levels in AIDS patients. CONCLUSIONS: Acute-phase inflammatory activity is associated with low serum retinol levels in individuals with AIDS.

Details

Title
Influence of acute-phase inflammatory response on serum levels of retinol and retinol binding protein in HIV/AIDS patients
Author
Neves, Fábio Fernandes; Figueiredo, José Fernando de Castro; Jordão, Júnior Alceu Afonso; Vannucchi, Hélio H.
Section
Articles
Publication year
2010
Publication date
Jan/Feb 2010
Publisher
Sociedade Brasileira de Medicina Tropical
ISSN
00378682
e-ISSN
16789849
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1449145076
Copyright
Copyright Sociedade Brasileira de Medicina Tropical Jan/Feb 2010