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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Meroterpenoids are secondary metabolites formed due to mixed biosynthetic pathways which are produced in part from a terpenoid co-substrate. These mixed biosynthetically hybrid compounds are widely produced by bacteria, algae, plants, and animals. Notably amazing chemical diversity is generated among meroterpenoids via a combination of terpenoid scaffolds with polyketides, alkaloids, phenols, and amino acids. This review deals with the isolation, chemical diversity, and biological effects of 452 new meroterpenoids reported from natural sources from January 2016 to December 2020. Most of the meroterpenoids possess antimicrobial, cytotoxic, antioxidant, anti-inflammatory, antiviral, enzyme inhibitory, and immunosupressive effects.

Details

Title
Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology
Author
Nazir, Mamona 1 ; Saleem, Muhammad 2   VIAFID ORCID Logo  ; Tousif, Muhammad Imran 3   VIAFID ORCID Logo  ; Muhammad Aijaz Anwar 4 ; Surup, Frank 5   VIAFID ORCID Logo  ; Ali, Iftikhar 6   VIAFID ORCID Logo  ; Wang, Daijie 7 ; Mamadalieva, Nilufar Z 8   VIAFID ORCID Logo  ; Alshammari, Elham 9   VIAFID ORCID Logo  ; Ashour, Mohamed L 10   VIAFID ORCID Logo  ; Ashour, Ahmed M 11   VIAFID ORCID Logo  ; Ahmed, Ishtiaq 12 ; Elizbit  13 ; Green, Ivan R 14   VIAFID ORCID Logo  ; Hidayat Hussain 15   VIAFID ORCID Logo 

 Department of Chemistry, Government Sadiq College Women University Bahawalpur, Bahawalpur 63100, Pakistan 
 Institute of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan; m.saleem@iub.edu.pk 
 Department of Chemistry, DG Khan Campus, University of Education Lahore, Dera Ghazi Khan 32200, Pakistan; imran.tousif@ue.edu.pk 
 Pharmaceutical Research Division, PCSIR Laboratories Complex Karachi, Karachi 75280, Pakistan; maanwarpk@yahoo.com 
 Microbial Drugs, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany; Frank.Surup@helmholtz-hzi.de 
 School of Pharmaceutical Sciences and Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province, Shandong Analysis and Test Center, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China; iftikhar.ali@kiu.edu.pk (I.A.); wangdaijie@qlu.edu.cn (D.W.); Department of Chemistry, Karakoram International University, Gilgit 15100, Pakistan 
 School of Pharmaceutical Sciences and Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province, Shandong Analysis and Test Center, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China; iftikhar.ali@kiu.edu.pk (I.A.); wangdaijie@qlu.edu.cn (D.W.) 
 Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, D-06120 Halle, Germany; nmamadalieva@yahoo.com; Institute of the Chemistry of Plant Substances, Uzbekistan Academy of Sciences, Mirzo Ulugbek Str 77, Tashkent 100170, Uzbekistan 
 Department of Pharmacy Practice, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia; ejalshammari@pnu.edu.sa 
10  Department of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, Jeddah 21442, Saudi Arabia; mohamed.ashour@bmc.edu.sa or ; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt 
11  Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, P.O. Box 13578, Makkah 21955, Saudi Arabia; amashour@uqu.edu.sa 
12  Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 1TN, UK 
13  Department of Materials Engineering, National University of Sciences and Technology (NUST) H12, Islamabad 44000, Pakistan; malkaalizachem@gmail.com 
14  Department of Chemistry and Polymer Science, University of Stellenbosch, Private Bag X1, Matieland, Stellenbosch 7600, South Africa; irg@sun.ac.za 
15  Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, D-06120 Halle, Germany; nmamadalieva@yahoo.com 
First page
957
Publication year
2021
Publication date
2021
Publisher
MDPI AG
e-ISSN
2218273X
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2554441358
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.