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Abstract

Objective

Increased numbers of tumor-infiltrating lymphocytes (TILs) in high-grade serous ovarian cancer (HGSC) are associated with improved clinical outcome. Intraepithelial localization of TILs might be regulated by specific homing receptors, such as CD103, which is widely expressed by intraepithelial lymphocytes. Given the emerging role of CD103+ TILs, we aimed to assess their contribution to the prognostic value of immunoscoring in HGSC.

Methods

The density of intratumoral CD3+ and CD103+ lymphocytes was examined by immunohistochemistry on a tissue microarray of a series of 135 patients with advanced HGSC and correlated with CD4+, CD8+, CD56+, FoxP3+, and TCRγ+ T-cell counts, as well as E-cadherin staining and conventional prognostic parameters and clinical outcome.

Results

Both the presence of CD103+ cells, as well as high numbers of intraepithelial CD3+ lymphocytes (CD3E), showed a significant correlation with overall survival, in the complete series, as well as in patients with optimal debulking and/or platinum sensitivity. Combining CD3 and CD103 counts improved prognostication and identified 3 major subgroups with respect to overall survival. The most pronounced effect was demonstrated for patients with optimally resected and platinum-sensitive tumors. Patients with CD3high/CD103high tumors showed a 5-year survival rate at 90%, CD3low/CD103high at 63%, and CD3low/CD103low at 0% (P < 0.001).

Conclusions

These results suggest that combined assessment of CD103 and CD3 counts improves the prognostic value of TIL counts in HGSC and might identify patients with early relapse or long-term survival based on the type and extent of the immune response.

Details

Title
Combined Immunoscore of CD103 and CD3 Identifies Long-Term Survivors in High-Grade Serous Ovarian Cancer
Author
Hans-Christian Bösmüller; Wagner, Philipp; Peper, Janet Kerstin; Schuster, Heiko; Deborah Lam Pham; Greif, Karen; Beschorner, Christine; Rammensee, Hans-Georg; Stevanović, Stefan; Fend, Falko; Staebler, Annette
Pages
671-679
Section
Ovarian Cancer
Publication year
2016
Publication date
May 2016
Publisher
Elsevier Limited
ISSN
1048891X
e-ISSN
15251438
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2579087565
Copyright
© 2016 2016 by the International Gynecologic Cancer Society and the European Society of Gynaecological Oncology.